The complete genome sequence of the gastric pathogen Helicobacter pylori.

@article{citeulike:118829, abstract = {Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH.}, address = {The Institute for Genomic Research, Rockville, Maryland 20850, USA. ghp@tigr.org}, author = {Tomb, J. F. and White, O. and Kerlavage, A. R. and Clayton, R. A. and Sutton, G. G. and Fleischmann, R. D. and Ketchum, K. A. and Klenk, H. P. and Gill, S. and Dougherty, B. A. and Nelson, K. and Quackenbush, J. and Zhou, L. and Kirkness, E. F. and Peterson, S. and Loftus, B. and Richardson, D. and Dodson, R. and Khalak, H. G. and Glodek, A. and McKenney, K. and Fitzegerald, L. M. and Lee, N. and Adams, M. D. and Venter, J. C. }, citeulike-article-id = {118829}, doi = {http://dx.doi.org/10.1038/41483}, issn = {0028-0836}, journal = {Nature}, keywords = {genomics, pylori, sequencing}, month = {August}, number = {6642}, pages = {539--547}, posted-at = {2008-03-19 23:53:19}, priority = {2}, title = {The complete genome sequence of the gastric pathogen Helicobacter pylori.}, url = {http://dx.doi.org/10.1038/41483}, volume = {388}, year = {1997} }

TY - JOUR ID - citeulike:118829 L3 - citeulike-article-id:118829 TI - The complete genome sequence of the gastric pathogen Helicobacter pylori. JF - Nature VL - 388 IS - 6642 SP - 539 EP - 547 AD - The Institute for Genomic Research, Rockville, Maryland 20850, USA. ghp@tigr.org SN - 0028-0836 N2 - Helicobacter pylori, strain 26695, has a circular genome of 1,667,867 base pairs and 1,590 predicted coding sequences. Sequence analysis indicates that H. pylori has well-developed systems for motility, for scavenging iron, and for DNA restriction and modification. Many putative adhesins, lipoproteins and other outer membrane proteins were identified, underscoring the potential complexity of host-pathogen interaction. Based on the large number of sequence-related genes encoding outer membrane proteins and the presence of homopolymeric tracts and dinucleotide repeats in coding sequences, H. pylori, like several other mucosal pathogens, probably uses recombination and slipped-strand mispairing within repeats as mechanisms for antigenic variation and adaptive evolution. Consistent with its restricted niche, H. pylori has a few regulatory networks, and a limited metabolic repertoire and biosynthetic capacity. Its survival in acid conditions depends, in part, on its ability to establish a positive inside-membrane potential in low pH. KW - genomics KW - pylori KW - sequencing AU - Tomb, JF AU - White, O AU - Kerlavage, AR AU - Clayton, RA AU - Sutton, GG AU - Fleischmann, RD AU - Ketchum, KA AU - Klenk, HP AU - Gill, S AU - Dougherty, BA AU - Nelson, K AU - Quackenbush, J AU - Zhou, L AU - Kirkness, EF AU - Peterson, S AU - Loftus, B AU - Richardson, D AU - Dodson, R AU - Khalak, HG AU - Glodek, A AU - McKenney, K AU - Fitzegerald, LM AU - Lee, N AU - Adams, MD AU - Venter, JC PY - 1997/08/07/ UR - http://dx.doi.org/10.1038/41483 ER -