Genomic imprinting: CTCF protects the boundaries.

@article{citeulike:2938415, abstract = {The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.}, address = {Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK.}, author = {Lewis, A. and Murrell, A. }, citeulike-article-id = {2938415}, doi = {http://dx.doi.org/10.1016/j.cub.2004.03.026}, issn = {0960-9822}, journal = {Current biology : CB}, keywords = {ctcf, h19, icr, imprinting}, month = {April}, number = {7}, posted-at = {2008-06-28 00:48:45}, priority = {0}, title = {Genomic imprinting: CTCF protects the boundaries.}, url = {http://dx.doi.org/10.1016/j.cub.2004.03.026}, volume = {14}, year = {2004} }

TY - JOUR ID - citeulike:2938415 L3 - citeulike-article-id:2938415 TI - Genomic imprinting: CTCF protects the boundaries. JF - Current biology : CB VL - 14 IS - 7 AD - Laboratory of Developmental Genetics and Imprinting, Developmental Genetics Programme, The Babraham Institute, Cambridge, CB2 4AT, UK. SN - 0960-9822 N2 - The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline. KW - ctcf KW - h19 KW - icr KW - imprinting AU - Lewis, A AU - Murrell, A PY - 2004/04/06/ UR - http://dx.doi.org/10.1016/j.cub.2004.03.026 ER -