Sertraline hepatotoxicity: a case report and review of the literature on selective serotonin reuptake inhibitor hepatotoxicity.

by: S Persky, JF Reinus

Digestive diseases and sciences, Vol. 48, No. 5. (May 2003), pp. 939-944.

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The causal role of sertraline in rare cases of liver failure in patients taking the drug has not been proven in a manner consistent with usually accepted standards. We describe an individual who developed clinically significant hepatitis while being treated with sertraline. This case is significant because it is the only one of which we are aware in which the diagnosis of sertraline hepatotoxicity was confirmed when inadvertent rechallenge with the medication resulted in recurrent hepatitis. We review this case and the general role of this widely prescribed class of drugs in causing hepatitis.

@article{citeulike:2828235, abstract = {The causal role of sertraline in rare cases of liver failure in patients taking the drug has not been proven in a manner consistent with usually accepted standards. We describe an individual who developed clinically significant hepatitis while being treated with sertraline. This case is significant because it is the only one of which we are aware in which the diagnosis of sertraline hepatotoxicity was confirmed when inadvertent rechallenge with the medication resulted in recurrent hepatitis. We review this case and the general role of this widely prescribed class of drugs in causing hepatitis.}, address = {Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA.}, author = {Persky, S. and Reinus, J. F. }, citeulike-article-id = {2828235}, issn = {0163-2116}, journal = {Digestive diseases and sciences}, keywords = {anti\_depressant, gi, side\_effect}, month = {May}, number = {5}, pages = {939--944}, posted-at = {2008-05-24 22:47:16}, priority = {0}, title = {Sertraline hepatotoxicity: a case report and review of the literature on selective serotonin reuptake inhibitor hepatotoxicity.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/12772794}, volume = {48}, year = {2003} }

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TY - JOUR ID - citeulike:2828235 L3 - citeulike-article-id:2828235 TI - Sertraline hepatotoxicity: a case report and review of the literature on selective serotonin reuptake inhibitor hepatotoxicity. JF - Digestive diseases and sciences VL - 48 IS - 5 SP - 939 EP - 944 AD - Division of Gastroenterology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, New York 10467, USA. SN - 0163-2116 N2 - The causal role of sertraline in rare cases of liver failure in patients taking the drug has not been proven in a manner consistent with usually accepted standards. We describe an individual who developed clinically significant hepatitis while being treated with sertraline. This case is significant because it is the only one of which we are aware in which the diagnosis of sertraline hepatotoxicity was confirmed when inadvertent rechallenge with the medication resulted in recurrent hepatitis. We review this case and the general role of this widely prescribed class of drugs in causing hepatitis. KW - anti_depressant KW - gi KW - side_effect AU - Persky, S AU - Reinus, JF PY - 2003/05// UR - http://view.ncbi.nlm.nih.gov/pubmed/12772794 ER -

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