Functional integration across a gradient of corticostriatal channels controls UP state transitions in the dorsal striatum

@article{citeulike:2882280, abstract = {Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome of such spiraling remains to be identified. Here, we examined whether plateau depolarizations (UP states) in striatal neurons relate better to active epochs in local field potentials recorded from closely related cortical areas than to those recorded in less-related cortical areas. Our results show that, in anesthetized rats, the coordination between cortical areas and striatal regions obeys a mediolateral gradient and keeps track of slow wave trajectory across the neocortex. Moreover, activity in one cortical area induced phase advances in UP state onset and phase delays in UP state termination in nonmatching striatal regions, reflecting the existence of functional connections that could encode large-scale interactions between corticostriatal channels as subthreshold influences on striatal projection neurons. 10.1073/pnas.0711113105}, author = {Kasanetz, Fernando and Riquelme, Luis A. and Della-Maggiore, Valeria and O'Donnell, Patricio and Murer, Gustavo M. }, citeulike-article-id = {2882280}, doi = {http://dx.doi.org/10.1073/pnas.0711113105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {anaesthesia, dorsal\_striatum, spiral, striatum, upstate}, month = {June}, number = {23}, pages = {8124--8129}, posted-at = {2008-06-11 09:43:04}, priority = {2}, title = {Functional integration across a gradient of corticostriatal channels controls UP state transitions in the dorsal striatum}, url = {http://dx.doi.org/10.1073/pnas.0711113105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:2882280 L3 - citeulike-article-id:2882280 TI - Functional integration across a gradient of corticostriatal channels controls UP state transitions in the dorsal striatum JF - Proceedings of the National Academy of Sciences VL - 105 IS - 23 SP - 8124 EP - 8129 N2 - Coordinated near-threshold depolarized states in cortical and striatal neurons may contribute to form functionally segregated channels of information processing. Recent anatomical studies have identified pathways that could support spiraling interactions across corticostriatal channels, but a functional outcome of such spiraling remains to be identified. Here, we examined whether plateau depolarizations (UP states) in striatal neurons relate better to active epochs in local field potentials recorded from closely related cortical areas than to those recorded in less-related cortical areas. Our results show that, in anesthetized rats, the coordination between cortical areas and striatal regions obeys a mediolateral gradient and keeps track of slow wave trajectory across the neocortex. Moreover, activity in one cortical area induced phase advances in UP state onset and phase delays in UP state termination in nonmatching striatal regions, reflecting the existence of functional connections that could encode large-scale interactions between corticostriatal channels as subthreshold influences on striatal projection neurons. 10.1073/pnas.0711113105 KW - anaesthesia KW - dorsal_striatum KW - spiral KW - striatum KW - upstate AU - Kasanetz, Fernando AU - Riquelme, Luis AU - Della-Maggiore, Valeria AU - O'Donnell, Patricio AU - Murer, Gustavo PY - 2008/06/10/ UR - http://dx.doi.org/10.1073/pnas.0711113105 ER -