Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization.

@article{citeulike:2615392, abstract = {The prefrontal cortex and the hippocampus exhibit converging projections to the nucleus accumbens and have functional reciprocal connections via indirect pathways. As a result, information processing between these structures is likely to be bidirectional. Using evoked potential measures, we examined the interactions of these inputs on synaptic plasticity within the accumbens. Our results show that the direction of information flow between the prefrontal cortex and limbic structures determines the synaptic plasticity that these inputs exhibit within the accumbens. Moreover, this synaptic plasticity at hippocampal and prefrontal inputs selectively involves dopamine D1 and D2 activation or inactivation, respectively. Repeated cocaine administration disrupted this synaptic plasticity at hippocampal and prefrontal cortical inputs and goal-directed behavior in the spatial maze task. Thus, interactions of limbic-prefrontal cortical synaptic plasticity and its dysfunction within the accumbens could underlie complex information processing deficits observed in individuals following psychostimulant administration.}, address = {Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. goto@bns.pitt.edu}, author = {Goto, Y. and Grace, A. A. }, citeulike-article-id = {2615392}, doi = {10.1016/j.neuron.2005.06.017}, issn = {0896-6273}, journal = {Neuron}, keywords = {cocaine, dopamine, drugs, hippocampus, pfc, plasticity}, month = {July}, number = {2}, pages = {255--266}, posted-at = {2008-03-31 09:34:02}, priority = {2}, title = {Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization.}, url = {http://dx.doi.org/10.1016/j.neuron.2005.06.017}, volume = {47}, year = {2005} }

TY - JOUR ID - citeulike:2615392 L3 - citeulike-article-id:2615392 TI - Dopamine-dependent interactions between limbic and prefrontal cortical plasticity in the nucleus accumbens: disruption by cocaine sensitization. JF - Neuron VL - 47 IS - 2 SP - 255 EP - 266 AD - Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA 15260, USA. goto@bns.pitt.edu SN - 0896-6273 N2 - The prefrontal cortex and the hippocampus exhibit converging projections to the nucleus accumbens and have functional reciprocal connections via indirect pathways. As a result, information processing between these structures is likely to be bidirectional. Using evoked potential measures, we examined the interactions of these inputs on synaptic plasticity within the accumbens. Our results show that the direction of information flow between the prefrontal cortex and limbic structures determines the synaptic plasticity that these inputs exhibit within the accumbens. Moreover, this synaptic plasticity at hippocampal and prefrontal inputs selectively involves dopamine D1 and D2 activation or inactivation, respectively. Repeated cocaine administration disrupted this synaptic plasticity at hippocampal and prefrontal cortical inputs and goal-directed behavior in the spatial maze task. Thus, interactions of limbic-prefrontal cortical synaptic plasticity and its dysfunction within the accumbens could underlie complex information processing deficits observed in individuals following psychostimulant administration. KW - cocaine KW - dopamine KW - drugs KW - hippocampus KW - pfc KW - plasticity AU - Goto, Y AU - Grace, AA PY - 2005/07/21/ UR - http://dx.doi.org/10.1016/j.neuron.2005.06.017 ER -