Behavioral Phenotyping Strategies for Mutant Mice

@article{citeulike:2601601, abstract = {Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the functional roles of many genes in the brain. Over the past 10 years, strategies for mouse behavioral phenotyping have evolved to maximize the scope and replicability of findings from a cohort of mutant mice, minimize the interpretation of procedural artifacts, and provide robust translational tools to test hypotheses and develop treatments. This Primer addresses experimental design issues and offers examples of high-throughput batteries, learning and memory tasks, and anxiety-related tests.}, author = {Crawley, Jacqueline N. }, citeulike-article-id = {2601601}, doi = {10.1016/j.neuron.2008.03.001}, journal = {Neuron}, keywords = {knockout, methods, mice}, month = {March}, number = {6}, pages = {809--818}, posted-at = {2008-03-27 11:46:39}, priority = {2}, title = {Behavioral Phenotyping Strategies for Mutant Mice}, url = {http://dx.doi.org/10.1016/j.neuron.2008.03.001}, volume = {57}, year = {2008} }

TY - JOUR ID - citeulike:2601601 L3 - citeulike-article-id:2601601 TI - Behavioral Phenotyping Strategies for Mutant Mice JF - Neuron VL - 57 IS - 6 SP - 809 EP - 818 N2 - Comprehensive behavioral analyses of transgenic and knockout mice have successfully identified the functional roles of many genes in the brain. Over the past 10 years, strategies for mouse behavioral phenotyping have evolved to maximize the scope and replicability of findings from a cohort of mutant mice, minimize the interpretation of procedural artifacts, and provide robust translational tools to test hypotheses and develop treatments. This Primer addresses experimental design issues and offers examples of high-throughput batteries, learning and memory tasks, and anxiety-related tests. KW - knockout KW - methods KW - mice AU - Crawley, Jacqueline PY - 2008/03/27/ UR - http://dx.doi.org/10.1016/j.neuron.2008.03.001 ER -