BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area

by: Kimberlee D'Ardenne, Samuel M Mcclure, Leigh E Nystrom, Jonathan D Cohen

Science, Vol. 319, No. 5867. (29 February 2008), pp. 1264-1267.

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Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (VStr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen leveldependent (BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events. 10.1126/science.1150605

@article{citeulike:2447209, abstract = {Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (VStr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen leveldependent (BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events. 10.1126/science.1150605}, author = {D'Ardenne, Kimberlee and Mcclure, Samuel M. and Nystrom, Leigh E. and Cohen, Jonathan D. }, citeulike-article-id = {2447209}, doi = {10.1126/science.1150605}, journal = {Science}, keywords = {dopamine, fmri, reward, td, vta}, month = {February}, number = {5867}, pages = {1264--1267}, posted-at = {2008-02-29 10:21:30}, priority = {2}, title = {BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area}, url = {http://dx.doi.org/10.1126/science.1150605}, volume = {319}, year = {2008} }

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TY - JOUR ID - citeulike:2447209 L3 - citeulike-article-id:2447209 TI - BOLD Responses Reflecting Dopaminergic Signals in the Human Ventral Tegmental Area JF - Science VL - 319 IS - 5867 SP - 1264 EP - 1267 N2 - Current theories hypothesize that dopamine neuronal firing encodes reward prediction errors. Although studies in nonhuman species provide direct support for this theory, functional magnetic resonance imaging (fMRI) studies in humans have focused on brain areas targeted by dopamine neurons [ventral striatum (VStr)] rather than on brainstem dopaminergic nuclei [ventral tegmental area (VTA) and substantia nigra]. We used fMRI tailored to directly image the brainstem. When primary rewards were used in an experiment, the VTA blood oxygen leveldependent (BOLD) response reflected a positive reward prediction error, whereas the VStr encoded positive and negative reward prediction errors. When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events. 10.1126/science.1150605 KW - dopamine KW - fmri KW - reward KW - td KW - vta AU - D'Ardenne, Kimberlee AU - Mcclure, Samuel AU - Nystrom, Leigh AU - Cohen, Jonathan PY - 2008/02/29/ UR - http://dx.doi.org/10.1126/science.1150605 ER -

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