Serotoninergic regulation of emotional and behavioural control processes

@article{citeulike:2191290, abstract = {5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional, cognitive and behavioural control processes. However, its precise contribution is still not well understood. Depletion of 5-HT enhances behavioural and brain responsiveness to punishment or other aversive signals, while disinhibiting previously rewarded but now punished behaviours. Findings suggest that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition. Exaggerated aversive processing and deficient response inhibition could underlie distinct symptoms of a range of affective disorders, namely stress- or threat-vulnerability and compulsive behaviour, respectively. We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects.}, author = {Cools, Roshan and Roberts, Angela C. and Robbins, Trevor W. }, citeulike-article-id = {2191290}, doi = {10.1016/j.tics.2007.10.011}, journal = {Trends in Cognitive Sciences}, keywords = {aversive, review, reward, serotonin}, month = {January}, number = {1}, pages = {31--40}, posted-at = {2008-01-04 10:00:24}, priority = {2}, title = {Serotoninergic regulation of emotional and behavioural control processes}, url = {http://dx.doi.org/10.1016/j.tics.2007.10.011}, volume = {12}, year = {2008} }

TY - JOUR ID - citeulike:2191290 L3 - citeulike-article-id:2191290 TI - Serotoninergic regulation of emotional and behavioural control processes JF - Trends in Cognitive Sciences VL - 12 IS - 1 SP - 31 EP - 40 N2 - 5-Hydroxytryptamine (5-HT, serotonin) has long been implicated in a wide variety of emotional, cognitive and behavioural control processes. However, its precise contribution is still not well understood. Depletion of 5-HT enhances behavioural and brain responsiveness to punishment or other aversive signals, while disinhibiting previously rewarded but now punished behaviours. Findings suggest that 5-HT modulates the impact of punishment-related signals on learning and emotion (aversion), but also promotes response inhibition. Exaggerated aversive processing and deficient response inhibition could underlie distinct symptoms of a range of affective disorders, namely stress- or threat-vulnerability and compulsive behaviour, respectively. We review evidence from studies with human volunteers and experimental animals that begins to elucidate the neurobiological systems underlying these different effects. KW - aversive KW - review KW - reward KW - serotonin AU - Cools, Roshan AU - Roberts, Angela AU - Robbins, Trevor PY - 2008/01// UR - http://dx.doi.org/10.1016/j.tics.2007.10.011 ER -