Estimating the size of the human interactome

by: Michael P Stumpf, Thomas Thorne, Eric de Silva, Ronald Stewart, Hyeong J An, Michael Lappe, Carsten Wiuf

Proceedings of the National Academy of Sciences (12 May 2008), 0708078105.

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Referat

After the completion of the human and other genome projects it emerged that the number of genes in organisms as diverse as fruit flies, nematodes, and humans does not reflect our perception of their relative complexity. Here, we provide reliable evidence that the size of protein interaction networks in different organisms appears to correlate much better with their apparent biological complexity. We develop a stable and powerful, yet simple, statistical procedure to estimate the size of the whole network from subnet data. This approach is then applied to a range of eukaryotic organisms for which extensive protein interaction data have been collected and we estimate the number of interactions in humans to be approx650,000. We find that the human interaction network is one order of magnitude bigger than the Drosophila melanogaster interactome and approx3 times bigger than in Caenorhabditis elegans. 10.1073/pnas.0708078105

@article{citeulike:2793797, abstract = {After the completion of the human and other genome projects it emerged that the number of genes in organisms as diverse as fruit flies, nematodes, and humans does not reflect our perception of their relative complexity. Here, we provide reliable evidence that the size of protein interaction networks in different organisms appears to correlate much better with their apparent biological complexity. We develop a stable and powerful, yet simple, statistical procedure to estimate the size of the whole network from subnet data. This approach is then applied to a range of eukaryotic organisms for which extensive protein interaction data have been collected and we estimate the number of interactions in humans to be {approx}650,000. We find that the human interaction network is one order of magnitude bigger than the Drosophila melanogaster interactome and {approx}3 times bigger than in Caenorhabditis elegans. 10.1073/pnas.0708078105}, author = {Stumpf, Michael P. and Thorne, Thomas and de Silva, Eric and Stewart, Ronald and An, Hyeong J. and Lappe, Michael and Wiuf, Carsten }, citeulike-article-id = {2793797}, doi = {10.1073/pnas.0708078105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {bioinformatics, human, interaction, interactome, network, prediction, protein-protein}, month = {May}, pages = {0708078105+}, posted-at = {2008-05-14 04:39:31}, priority = {2}, title = {Estimating the size of the human interactome}, url = {http://dx.doi.org/10.1073/pnas.0708078105}, year = {2008} }

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TY - JOUR ID - citeulike:2793797 L3 - citeulike-article-id:2793797 TI - Estimating the size of the human interactome JF - Proceedings of the National Academy of Sciences SP - 0708078105 N2 - After the completion of the human and other genome projects it emerged that the number of genes in organisms as diverse as fruit flies, nematodes, and humans does not reflect our perception of their relative complexity. Here, we provide reliable evidence that the size of protein interaction networks in different organisms appears to correlate much better with their apparent biological complexity. We develop a stable and powerful, yet simple, statistical procedure to estimate the size of the whole network from subnet data. This approach is then applied to a range of eukaryotic organisms for which extensive protein interaction data have been collected and we estimate the number of interactions in humans to be {approx}650,000. We find that the human interaction network is one order of magnitude bigger than the Drosophila melanogaster interactome and {approx}3 times bigger than in Caenorhabditis elegans. 10.1073/pnas.0708078105 KW - bioinformatics KW - human KW - interaction KW - interactome KW - network KW - prediction KW - protein-protein AU - Stumpf, Michael AU - Thorne, Thomas AU - de Silva, Eric AU - Stewart, Ronald AU - An, Hyeong AU - Lappe, Michael AU - Wiuf, Carsten PY - 2008/05/12/ UR - http://dx.doi.org/10.1073/pnas.0708078105 ER -

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