Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex

by: James Schummers, Hongbo Yu, Mriganka Sur

Science, Vol. 320, No. 5883. (20 June 2008), pp. 1638-1643.

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Referat

Astrocytes have long been thought to act as a support network for neurons, with little role in information representation or processing. We used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive fields and sharp tuning to visual stimulus features including orientation and spatial frequency. The stimulus-feature preferences of astrocytes were exquisitely mapped across the cortical surface, in close register with neuronal maps. The spatially restricted stimulus-specific component of the intrinsic hemodynamic mapping signal was highly sensitive to astrocyte activation, indicating that astrocytes have a key role in coupling neuronal organization to mapping signals critical for noninvasive brain imaging. Furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses. 10.1126/science.1156120

@article{citeulike:2910062, abstract = {Astrocytes have long been thought to act as a support network for neurons, with little role in information representation or processing. We used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive fields and sharp tuning to visual stimulus features including orientation and spatial frequency. The stimulus-feature preferences of astrocytes were exquisitely mapped across the cortical surface, in close register with neuronal maps. The spatially restricted stimulus-specific component of the intrinsic hemodynamic mapping signal was highly sensitive to astrocyte activation, indicating that astrocytes have a key role in coupling neuronal organization to mapping signals critical for noninvasive brain imaging. Furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses. 10.1126/science.1156120}, author = {Schummers, James and Yu, Hongbo and Sur, Mriganka }, citeulike-article-id = {2910062}, doi = {http://dx.doi.org/10.1126/science.1156120}, journal = {Science}, keywords = {astrocyte, ferret, hemodynamics, twophoton, vision}, month = {June}, number = {5883}, pages = {1638--1643}, posted-at = {2008-06-30 22:13:27}, priority = {2}, title = {Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex}, url = {http://dx.doi.org/10.1126/science.1156120}, volume = {320}, year = {2008} }

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TY - JOUR ID - citeulike:2910062 L3 - citeulike-article-id:2910062 TI - Tuned Responses of Astrocytes and Their Influence on Hemodynamic Signals in the Visual Cortex JF - Science VL - 320 IS - 5883 SP - 1638 EP - 1643 N2 - Astrocytes have long been thought to act as a support network for neurons, with little role in information representation or processing. We used two-photon imaging of calcium signals in the ferret visual cortex in vivo to discover that astrocytes, like neurons, respond to visual stimuli, with distinct spatial receptive fields and sharp tuning to visual stimulus features including orientation and spatial frequency. The stimulus-feature preferences of astrocytes were exquisitely mapped across the cortical surface, in close register with neuronal maps. The spatially restricted stimulus-specific component of the intrinsic hemodynamic mapping signal was highly sensitive to astrocyte activation, indicating that astrocytes have a key role in coupling neuronal organization to mapping signals critical for noninvasive brain imaging. Furthermore, blocking astrocyte glutamate transporters influenced the magnitude and duration of adjacent visually driven neuronal responses. 10.1126/science.1156120 KW - astrocyte KW - ferret KW - hemodynamics KW - twophoton KW - vision AU - Schummers, James AU - Yu, Hongbo AU - Sur, Mriganka PY - 2008/06/20/ UR - http://dx.doi.org/10.1126/science.1156120 ER -

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