Molecular probes: insights into design and analysis from computational and physical chemistry.

@article{citeulike:2721617, abstract = {The application of new molecular diagnostics to probe cellular process in vivo is leading to a greater understanding of molecular cytology at a sub-nanoscale level and is opening the way to individualized medicines. We review here three distinct fluorescence-based molecular probes, HyBeacons, split-probe exciplexes and GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) systems. Through this, we highlight the insights into the mechanism and design that a combined computational and experimental approach can yield.}, address = {Wolfson Centre for Structure-Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, U.K.}, author = {Mitchell, F. L. and Marks, G. E. and Bichenkova, E. V. and Douglas, K. T. and Bryce, R. A. }, citeulike-article-id = {2721617}, doi = {http://dx.doi.org/10.1042/BST0360046}, issn = {0300-5127}, journal = {Biochemical Society transactions}, month = {February}, number = {Pt 1}, pages = {46--50}, posted-at = {2008-04-26 13:41:45}, priority = {2}, title = {Molecular probes: insights into design and analysis from computational and physical chemistry.}, url = {http://dx.doi.org/10.1042/BST0360046}, volume = {36}, year = {2008} }

TY - JOUR ID - citeulike:2721617 L3 - citeulike-article-id:2721617 TI - Molecular probes: insights into design and analysis from computational and physical chemistry. JF - Biochemical Society transactions VL - 36 IS - Pt 1 SP - 46 EP - 50 AD - Wolfson Centre for Structure-Based Design of Molecular Diagnostics, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester M13 9PL, U.K. SN - 0300-5127 N2 - The application of new molecular diagnostics to probe cellular process in vivo is leading to a greater understanding of molecular cytology at a sub-nanoscale level and is opening the way to individualized medicines. We review here three distinct fluorescence-based molecular probes, HyBeacons, split-probe exciplexes and GFP (green fluorescent protein)-based FRET (fluorescence resonance energy transfer) systems. Through this, we highlight the insights into the mechanism and design that a combined computational and experimental approach can yield. AU - Mitchell, FL AU - Marks, GE AU - Bichenkova, EV AU - Douglas, KT AU - Bryce, RA PY - 2008/02// UR - http://dx.doi.org/10.1042/BST0360046 ER -