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Universal strategies in research and drug discovery based on protein-fragment complementation assaysNature Reviews Drug Discovery, Vol. 6, No. 7., pp. 569-582.
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BibTeX record RIS record2dge aa aborigine abpm abpp acarbose ace ace2 acei acetylation acid-base activity activity-based acute adam adenosine adipokine adiponectin adma adrenal adrenomedullin affinity affy aft age aging agreement ai aii akt album albumin alcohol aldh aldh2 aldosterone alignment allhat alpk1 ampk amplification analgesics ancova androgen anemia aneurysm angiogenesis anima animal ann annexin anorexia anova anp ans anthropometry antibiotics antibody antisense ap1 apc aplicing apoe apoptosis appetite aptamer arb ards arecoline arf arkadia arthritis ase asia aspirin assocation association assumption asymptote at1 at2 atm attirtion attrition autoantibody autoimminity autoimmunity automation autophagy avf b2m bac bacteria baculovirus bayes bcaa beta-adrenergic beta-blocker betel bia bias bifc biobank biofilm bioinformatics bioinformatis biomaker biomarker biopsy blast bleeding blood bma bmi bmp bmp7 bnp bone boosting bootstrap boratory bounded bp bun bv ca cachexia cachexmia cad cadium cadmium cage calcification calcimimetics calcium calmodulin calorimetry calpain camp cancer candiate-gene candidate-gene canitine capd cardiomegaly carnitine cartotenoid case-cohort case-control caspase catabolism catenin catheter causality causation caveolin ccb cd cd1 ce cel-array cell cell-adhesion cell-array cell-cycle cell-microarray censor ceramide cgh cgmp change changepoiint changepoint chaqngepoint chd chemical-genetics chemogenomics chemokine chemotherapy chf china chip chip-chip chip-cloning chip-snp chk cho cholinergic chromatography ciliopathy cin ck2 ckd classification clathrin cloning cluster clustering cmv cnv co coffee cohort colchicine collagen collinearity colon comet communication comorbidity company compeitive-pcr competing-risk competitive-pcr competivie-pcr complex compliance conditional confidence-interval confounding connexin control copper copula core-curriculum cortisol cost cost-efective cost-effect cost-effective cot-effective cotinine cox cox2 cqi creatinine creb cre-lox critical-care crossover cross-over cross-platform cross-species crp crrt cryopyrin ct ctgf curcumin cure cusum cv cxcr2 cyclin cyp450 cyst cystatin cytokine cytoscape cytoskeleton database data-mining dataset dbdb dc decorin decoy defensin delirium delivery dendritic-cell dentistry depression design dhplc diagnosis dialysate dialysis dialyzer diastolic dichotomization diet dige disease-management disparity distribution diuretics diurnal dm dn dna-adduct dna-da dna-damage dna-ddamage dna-pk dna-synthesis doca-salt dopamine dopps dose-reponse dose-response dpi drug drug-discovery dual duzzy dvt dyanamic-range dye-swap dynamic-range e2f ebm ebv ecm ecoli ecology edema education effect-size effusion egf egfr eia eicosanoid electrolyte electroporation electroporatrion electroportaion embryology emodin emsa emt enamia endothelial-dysfunction endothelium endotoxin endpoint energy enoxacin ent environment enzyme epidemiology epigenetic epigenetics epiregulin epistasis epithelium epo eqtl erk erm error er-stress esirna est estrogen ethics ets excel exercise extraction fak family fasting fat fbat fc fdr fetal fetuin ffpe ffq fgf fhs fibrinogen fibroblast fibromyalgia fibronectin fibrosis fish fish-oil flow-cytometry fluid fluorescence fly forest formaldehyde foxo fracpoly fractal fracture frailty fret fructose fto function functional-regression function-regression futility fuzzy fxr galectin gam gas gata gauss gb ge gee gelatin gencer gender gene gene-environment gene-gene gene-targeting gene-therapy genetics genome genomics geography gerd geriatric geriatrics gfr gh ghrelin gi glcnac gllamm glm glucose glut glutamine glycation glycemia glycmoics glycomics gn gne-gene gnetics gof good gout gpcr graph graphics gremlin grid grk grn gsk gsk3 gst guideline gwa gyn gynecomastia haplotype hapmap hba1c hbv hcc hcv hcy hd hdac hdf hdl hek293 hematuria hemoglobin heparin hepatotyte herb heritability hfe hg hgf hgp hif high-fat hirsutism histidine histone hiv hk2 hmgb hnf ho ho1 hospital hospital-based hospitalization housekeeping hp hrs hsc hsp ht hts huge hvj hwe hyaluronan hydrodynamic hyperfiltration hyperglycemia hyperlipidemia hyperosmolality hypertfiltration hypertonicity hypertrophy hypotension hypoxia icp-ms icu id identifier idn idw ie ief ifg1 ifn igf igf1 ih ihc ihg il il1 il6 ilk illumina image imaging imcd immortal-time-bias immunity immunoblot immuno-pcr impuputation imputaion imputation indel inducible infection inflammasome inflammasone inflammation inflammtion influenza informative-censor inhibitor insulin insulin-receptor integrin interaction interactome interval-censor intrumental-variable inverse-sampling ipcw ir iron irs ish isoform itraq iv jak japan jnk joint-model jun k kallikrein kallistatin kap keep kidney kidney-specific kim1 kinase kinin kinome kinomics klf klf5 kloho klotho knockout label-free laboratory lactase lasso latent latent-class latent-growth lbp lc lc-ms lcr ldl lead left-censor leptin lft lic lifestyle limma lims linux liongitudinal lipid lipidomics lipid-signaling liver llcpk1 llc-pk1 lna location lod logic-regression log-linear log-normal longitudinal low-density lox lpd lps lt lung lvh m macrophage management mao mapk markov mars mashup matching matlab mcp mcp1 mdck mdr mds measurement measurement-error meat mediation megalin megsin melanocortin melting-curve membran membrane membrane-protein mendelian menin mercury mesangial met meta-analysis meta-anaysis meta-anlysis metabolism metabolomics metagenomics metal method methylation mg mgo mia mice microanalysis microaray microarrapy microarray microfludics microfluidics micronucleus microscope milk mineral minipump mirna missing mitochondria mitogenesis mixed-effect mixed-effects mixed-model mixed-modl mixture mkicroarray mmf mmp model model-averaging model-organism model-selection molecular-beacon monotonic morality mortality mouse mrm mrp mrsa ms msh msm msp msu mthfr mthylation mtor multinomial multiplex multiplicicy multiplicity multivariate mutagenesis mv myc myd88 myosin n na nac nad nadph-oxidase nahsit nail name nash ncs necrosis nephrectomy nephrin nephrotoxicity nerve nested network netwrok neuro neurology nfkb ngal nhanes nhi niacin nicotinic nitration nitrosamine nlr nmf nnt no nonlinear nonparametric nonviral normality normalization notch ntuh nuclear-medicine nuclear-receptor nucleoside nucleus nutrigenomics nutrition nutrtion oat obesity occupation oct off-target oglcnac omics oncogene ontology ordinal osteopontin osteoporosis ou outcome outlier p p16 p21 p27 p2x p300 p38 p53 pad padlock pai1 pain palliative parp pathogenesis pathology pathway pbat pbmc pca pcr pd pde pdf pdgf pdk pdz pe pediatric pentoxifylline pentraxin periodontitis peritonitis pet pgc pgc1 pharmacogenetics phd phenotype phosdphorylation phosphatase phosphorylation phylogenetics pi pi3k pias1 pig pka pkc pkg pla pla2 placebo plasmapheresis plasmid platelet pld pls pmc pneumonia podocyte poisson polarity policy polyol pooling portal-ht power pp ppar ppara ppard pparg ppi ppm1a prb prealbumin prediction pregnancy presentation prevention primer production proliferation promoter propensity prostate protease proteasome protein protein-complex protein-microarray proteinuria proteomics pseudogene psychiatry pt pte pten pth ptm ptx pubmed pud purification p-value pyridoxamine qc qfia qol qtl quantitative r race radiology rage randomization rapamycin rap-pcr ras rat rb rbp rca rcr rct receptor recombineering recurrent recurrrent recutrrent reference reference-interval referral regeneration regneration regression relative-survival relaxin renalase renalse renin reporter-mouse research retinoid reuse reverse reverse-epidemiology rflp rho risk rnai robust roc ros rotein rppa rrf rt rtk s100 s6k safrole sage salicylate saliva salt sampling sarcopenia sarcopneia sas scaling screening seafood seasonal secretome seldi-tof sem semantic semiparametric senescence sensitivity sensor sepsis sequence 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