Going the distance: human population genetics in a clinal world

by: Lori J Handley, Andrea Manica, Jerome Goudet, Francois Balloux

Trends in Genetics, Vol. 23, No. 9. (September 2007), pp. 432-439.

View FullText article

DOI, ScienceDirect

Reviews [Write a review of this article]

There are no reviews of this article

Find related articles from these CiteULike users

joepickrell

Find related articles with these CiteULike tags

genetics, population

Referat

Global human genetic variation is greatly influenced by geography, with genetic differentiation between populations increasing with geographic distance and within-population diversity decreasing with distance from Africa. In fact, these 'clines' can explain most of the variation in human populations. Despite this, population genetics inferences often rely on models that do not take geography into account, which could result in misleading conclusions when working at global geographic scales. Geographically explicit approaches have great potential for the study of human population genetics. Here, we discuss the most promising avenues of research in the context of human settlement history and the detection of genomic elements under natural selection. We also review recent technical advances and address the challenges of integrating geography and genetics.

@article{citeulike:1577030, abstract = {Global human genetic variation is greatly influenced by geography, with genetic differentiation between populations increasing with geographic distance and within-population diversity decreasing with distance from Africa. In fact, these 'clines' can explain most of the variation in human populations. Despite this, population genetics inferences often rely on models that do not take geography into account, which could result in misleading conclusions when working at global geographic scales. Geographically explicit approaches have great potential for the study of human population genetics. Here, we discuss the most promising avenues of research in the context of human settlement history and the detection of genomic elements under natural selection. We also review recent technical advances and address the challenges of integrating geography and genetics.}, author = {Handley, Lori J. and Manica, Andrea and Goudet, Jerome and Balloux, Francois }, citeulike-article-id = {1577030}, doi = {http://dx.doi.org/10.1016/j.tig.2007.07.002}, journal = {Trends in Genetics}, keywords = {genetics, population}, month = {September}, number = {9}, pages = {432--439}, posted-at = {2007-08-20 16:38:22}, priority = {2}, title = {Going the distance: human population genetics in a clinal world}, url = {http://dx.doi.org/10.1016/j.tig.2007.07.002}, volume = {23}, year = {2007} }

RIS record

TY - JOUR ID - citeulike:1577030 L3 - citeulike-article-id:1577030 TI - Going the distance: human population genetics in a clinal world JF - Trends in Genetics VL - 23 IS - 9 SP - 432 EP - 439 N2 - Global human genetic variation is greatly influenced by geography, with genetic differentiation between populations increasing with geographic distance and within-population diversity decreasing with distance from Africa. In fact, these 'clines' can explain most of the variation in human populations. Despite this, population genetics inferences often rely on models that do not take geography into account, which could result in misleading conclusions when working at global geographic scales. Geographically explicit approaches have great potential for the study of human population genetics. Here, we discuss the most promising avenues of research in the context of human settlement history and the detection of genomic elements under natural selection. We also review recent technical advances and address the challenges of integrating geography and genetics. KW - genetics KW - population AU - Handley, Lori AU - Manica, Andrea AU - Goudet, Jerome AU - Balloux, Francois PY - 2007/09// UR - http://dx.doi.org/10.1016/j.tig.2007.07.002 ER -

RIS BibTeX