PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.

@article{citeulike:683079, abstract = {DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments.}, address = {Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts, USA.}, author = {Mootha, V. K. and Lindgren, C. M. and Eriksson, K. F. and Subramanian, A. and Sihag, S. and Lehar, J. and Puigserver, P. and Carlsson, E. and Ridderstr\r{a}le, M. and Laurila, E. and Houstis, N. and Daly, M. J. and Patterson, N. and Mesirov, J. P. and Golub, T. R. and Tamayo, P. and Spiegelman, B. and Lander, E. S. and Hirschhorn, J. N. and Altshuler, D. and Groop, L. C. }, citeulike-article-id = {683079}, doi = {10.1038/ng1180}, issn = {1061-4036}, journal = {Nat Genet}, keywords = {gene\_sets}, month = {July}, number = {3}, pages = {267--273}, posted-at = {2008-05-15 12:02:42}, priority = {2}, title = {PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes.}, url = {http://dx.doi.org/10.1038/ng1180}, volume = {34}, year = {2003} }

TY - JOUR ID - citeulike:683079 L3 - citeulike-article-id:683079 TI - PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. JF - Nat Genet VL - 34 IS - 3 SP - 267 EP - 273 AD - Whitehead Institute/MIT Center for Genome Research, Cambridge, Massachusetts, USA. SN - 1061-4036 N2 - DNA microarrays can be used to identify gene expression changes characteristic of human disease. This is challenging, however, when relevant differences are subtle at the level of individual genes. We introduce an analytical strategy, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes. Using this approach, we identify a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle. Expression of these genes is high at sites of insulin-mediated glucose disposal, activated by PGC-1alpha and correlated with total-body aerobic capacity. Our results associate this gene set with clinically important variation in human metabolism and illustrate the value of pathway relationships in the analysis of genomic profiling experiments. KW - gene_sets AU - Mootha, VK AU - Lindgren, CM AU - Eriksson, KF AU - Subramanian, A AU - Sihag, S AU - Lehar, J AU - Puigserver, P AU - Carlsson, E AU - Ridderstråle, M AU - Laurila, E AU - Houstis, N AU - Daly, MJ AU - Patterson, N AU - Mesirov, JP AU - Golub, TR AU - Tamayo, P AU - Spiegelman, B AU - Lander, ES AU - Hirschhorn, JN AU - Altshuler, D AU - Groop, LC PY - 2003/07// UR - http://dx.doi.org/10.1038/ng1180 ER -