The expanding transcriptome: the genome as the 'Book of Sand'

@article{citeulike:527427, abstract = {The central dogma of molecular biology inspired by classical work in prokaryotic organisms accounts for only part of the genetic agenda of complex eukaryotes. First, post-transcriptional events lead to the generation of multiple mRNAs, proteins and functions from a single primary transcript, revealing regulatory networks distinct in mechanism and biological function from those controlling RNA transcription. Second, a variety of populous families of small RNAs (small nuclear RNAs, small nucleolar RNAs, microRNAs, siRNAs and shRNAs) assemble on ribonucleoprotein complexes and regulate virtually all aspects of the gene expression pathway, with profound biological consequences. Third, high-throughput methods of genomic analysis reveal that RNAs other than non-protein-coding RNAs (ncRNAs) represent a major component of the transcriptome that may perform novel functions in gene regulation and beyond. Post-transcriptional regulation, small RNAs and ncRNAs provide an expanding picture of the transcriptome that enriches our views of what genes are, how they operate, evolve and are regulated.}, author = {Soares, Luis M. and Valcarcel, Juan }, citeulike-article-id = {527427}, doi = {10.1038/sj.emboj.7601023}, issn = {0261-4189}, journal = {EMBO Journal}, keywords = {functional\_genomics, non\_coding\_rna, review}, month = {March}, number = {5}, pages = {923--931}, posted-at = {2008-06-17 15:38:33}, priority = {2}, publisher = {Nature Publishing Group}, title = {The expanding transcriptome: the genome as the 'Book of Sand'}, url = {http://dx.doi.org/10.1038/sj.emboj.7601023}, volume = {25}, year = {2006} }

TY - JOUR ID - citeulike:527427 L3 - citeulike-article-id:527427 TI - The expanding transcriptome: the genome as the 'Book of Sand' JF - EMBO Journal VL - 25 IS - 5 SP - 923 EP - 931 PB - Nature Publishing Group SN - 0261-4189 N2 - The central dogma of molecular biology inspired by classical work in prokaryotic organisms accounts for only part of the genetic agenda of complex eukaryotes. First, post-transcriptional events lead to the generation of multiple mRNAs, proteins and functions from a single primary transcript, revealing regulatory networks distinct in mechanism and biological function from those controlling RNA transcription. Second, a variety of populous families of small RNAs (small nuclear RNAs, small nucleolar RNAs, microRNAs, siRNAs and shRNAs) assemble on ribonucleoprotein complexes and regulate virtually all aspects of the gene expression pathway, with profound biological consequences. Third, high-throughput methods of genomic analysis reveal that RNAs other than non-protein-coding RNAs (ncRNAs) represent a major component of the transcriptome that may perform novel functions in gene regulation and beyond. Post-transcriptional regulation, small RNAs and ncRNAs provide an expanding picture of the transcriptome that enriches our views of what genes are, how they operate, evolve and are regulated. KW - functional_genomics KW - non_coding_rna KW - review AU - Soares, Luis AU - Valcarcel, Juan PY - 2006/03/02/ UR - http://dx.doi.org/10.1038/sj.emboj.7601023 ER -