Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate

by: Honglu Zhang, Yong Xu, Nicolas Markadieu, Renaud Beauwens, Christophe Erneux, Glenn D Prestwich

Bioorganic & Medicinal Chemistry Letters, Vol. 18, No. 2. (15 January 2008), pp. 762-766.

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Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells.

@article{citeulike:2842496, abstract = {Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells.}, author = {Zhang, Honglu and Xu, Yong and Markadieu, Nicolas and Beauwens, Renaud and Erneux, Christophe and Prestwich, Glenn D. }, citeulike-article-id = {2842496}, doi = {10.1016/j.bmcl.2007.11.041}, journal = {Bioorganic \& Medicinal Chemistry Letters}, keywords = {phosphoinositides, pip2, pip3, synthesis}, month = {January}, number = {2}, pages = {762--766}, posted-at = {2008-05-28 19:34:13}, priority = {2}, title = {Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate}, url = {http://dx.doi.org/10.1016/j.bmcl.2007.11.041}, volume = {18}, year = {2008} }

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TY - JOUR ID - citeulike:2842496 L3 - citeulike-article-id:2842496 TI - Synthesis and biological activity of phosphatidylinositol-3,4,5-trisphosphorothioate JF - Bioorganic & Medicinal Chemistry Letters VL - 18 IS - 2 SP - 762 EP - 766 N2 - Metabolically-stabilized analogs of PtdIns(3,4,5)P3 have shown long-lived agonist activity for cellular events mediated by this phosphoinositide. We describe an efficient method for the total asymmetric synthesis of the trisphosphorothioate (PT) analog of PtdIns(3,4,5)P3. Intracellular delivery of dipalmitoyl PtdIns(3,4,5)PT3-mimicked insulin in activating sodium transport in A6 cells. KW - phosphoinositides KW - pip2 KW - pip3 KW - synthesis AU - Zhang, Honglu AU - Xu, Yong AU - Markadieu, Nicolas AU - Beauwens, Renaud AU - Erneux, Christophe AU - Prestwich, Glenn PY - 2008/01/15/ UR - http://dx.doi.org/10.1016/j.bmcl.2007.11.041 ER -

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