Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila

by: Ke Zhang, Jian Z Guo, Yueqing Peng, Wang Xi, Aike Guo

Science, Vol. 316, No. 5833. (29 June 2007), pp. 1901-1904.

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Referat

Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila. 10.1126/science.1137357

@article{citeulike:1421811, abstract = {Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila. 10.1126/science.1137357}, author = {Zhang, Ke and Guo, Jian Z. and Peng, Yueqing and Xi, Wang and Guo, Aike }, citeulike-article-id = {1421811}, doi = {10.1126/science.1137357}, journal = {Science}, keywords = {bodies, decision-making, drosophila, learning, memory, mushroom, visual}, month = {June}, number = {5833}, pages = {1901--1904}, posted-at = {2007-06-29 09:24:12}, priority = {0}, title = {Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila}, url = {http://dx.doi.org/10.1126/science.1137357}, volume = {316}, year = {2007} }

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TY - JOUR ID - citeulike:1421811 L3 - citeulike-article-id:1421811 TI - Dopamine-Mushroom Body Circuit Regulates Saliency-Based Decision-Making in Drosophila JF - Science VL - 316 IS - 5833 SP - 1901 EP - 1904 N2 - Drosophila melanogaster can make appropriate choices among alternative flight options on the basis of the relative salience of competing visual cues. We show that this choice behavior consists of early and late phases; the former requires activation of the dopaminergic system and mushroom bodies, whereas the latter is independent of these activities. Immunohistological analysis showed that mushroom bodies are densely innervated by dopaminergic axons. Thus, the circuit from the dopamine system to mushroom bodies is crucial for choice behavior in Drosophila. 10.1126/science.1137357 KW - bodies KW - decision-making KW - drosophila KW - learning KW - memory KW - mushroom KW - visual AU - Zhang, Ke AU - Guo, Jian AU - Peng, Yueqing AU - Xi, Wang AU - Guo, Aike PY - 2007/06/29/ UR - http://dx.doi.org/10.1126/science.1137357 ER -

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