Regulation of firing of dopaminergic neurons and control of goal-directed behaviors

@article{citeulike:1206070, abstract = {There are several brain regions that have been implicated in the control of motivated behavior and whose disruption leads to the pathophysiology observed in major psychiatric disorders. These systems include the ventral hippocampus, which is involved in context and focus on tasks, the amygdala, which mediates emotional behavior, and the prefrontal cortex, which modulates activity throughout the limbic system to enable behavioral flexibility. Each of these systems has overlapping projections to the nucleus accumbens, where these inputs are integrated under the modulatory influence of dopamine. Here, we provide a systems-oriented approach to interpreting the function of the dopamine system, its modulation of limbic-cortical interactions and how disruptions within this system might underlie the pathophysiology of schizophrenia and drug abuse.}, author = {Grace, Anthony A. and Floresco, Stan B. and Goto, Yukiori and Lodge, Daniel J. }, citeulike-article-id = {1206070}, doi = {10.1016/j.tins.2007.03.003}, journal = {Trends in Neurosciences}, keywords = {behavior, decision-making, habit, instrumental, learning, neurobiology, neuroscience, operant, psychology}, posted-at = {2007-09-06 13:01:49}, priority = {3}, title = {Regulation of firing of dopaminergic neurons and control of goal-directed behaviors}, url = {http://dx.doi.org/10.1016/j.tins.2007.03.003}, volume = {In Press, Corrected Proof} }

TY - JOUR ID - citeulike:1206070 TI - Regulation of firing of dopaminergic neurons and control of goal-directed behaviors JF - Trends in Neurosciences VL - In Press, Corrected Proof N2 - There are several brain regions that have been implicated in the control of motivated behavior and whose disruption leads to the pathophysiology observed in major psychiatric disorders. These systems include the ventral hippocampus, which is involved in context and focus on tasks, the amygdala, which mediates emotional behavior, and the prefrontal cortex, which modulates activity throughout the limbic system to enable behavioral flexibility. Each of these systems has overlapping projections to the nucleus accumbens, where these inputs are integrated under the modulatory influence of dopamine. Here, we provide a systems-oriented approach to interpreting the function of the dopamine system, its modulation of limbic-cortical interactions and how disruptions within this system might underlie the pathophysiology of schizophrenia and drug abuse. KW - behavior KW - decision-making KW - habit KW - instrumental KW - learning KW - neurobiology KW - neuroscience KW - operant KW - psychology AU - Grace, Anthony AU - Floresco, Stan AU - Goto, Yukiori AU - Lodge, Daniel UR - http://dx.doi.org/10.1016/j.tins.2007.03.003 ER -