The biological effects of simple tandem repeats: Lessons from the repeat expansion diseases

@article{citeulike:2949069, abstract = {Tandem repeats are common features of both prokaryote and eukaryote genomes, where they can be found not only in intergenic regions but also in both the noncoding and coding regions of a variety of different genes. The repeat expansion diseases are a group of human genetic disorders caused by long and highly polymorphic tandem repeats. These disorders provide many examples of the effects that such repeats can have on many biological processes. While repeats in the coding sequence can result in the generation of toxic or malfunctioning proteins, noncoding repeats can also have significant effects including the generation of chromosome fragility, the silencing of the genes in which they are located, the modulation of transcription and translation, and the sequestering of proteins involved in processes such as splicing and cell architecture. 10.1101/gr.070409.107}, author = {Usdin, Karen }, citeulike-article-id = {2949069}, doi = {10.1101/gr.070409.107}, journal = {Genome Res.}, keywords = {functional-genome, gene-expression, genome-sequencing, genome-structure}, month = {July}, number = {7}, pages = {1011--1019}, posted-at = {2008-07-01 20:19:03}, priority = {2}, title = {The biological effects of simple tandem repeats: Lessons from the repeat expansion diseases}, url = {http://dx.doi.org/10.1101/gr.070409.107}, volume = {18}, year = {2008} }

TY - JOUR ID - citeulike:2949069 L3 - citeulike-article-id:2949069 TI - The biological effects of simple tandem repeats: Lessons from the repeat expansion diseases JF - Genome Res. VL - 18 IS - 7 SP - 1011 EP - 1019 N2 - Tandem repeats are common features of both prokaryote and eukaryote genomes, where they can be found not only in intergenic regions but also in both the noncoding and coding regions of a variety of different genes. The repeat expansion diseases are a group of human genetic disorders caused by long and highly polymorphic tandem repeats. These disorders provide many examples of the effects that such repeats can have on many biological processes. While repeats in the coding sequence can result in the generation of toxic or malfunctioning proteins, noncoding repeats can also have significant effects including the generation of chromosome fragility, the silencing of the genes in which they are located, the modulation of transcription and translation, and the sequestering of proteins involved in processes such as splicing and cell architecture. 10.1101/gr.070409.107 KW - functional-genome KW - gene-expression KW - genome-sequencing KW - genome-structure AU - Usdin, Karen PY - 2008/07/01/ UR - http://dx.doi.org/10.1101/gr.070409.107 ER -