Inaugural Article: The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion

@article{citeulike:2925451, abstract = {The counterclockwise coiling of the intestines is initiated by a leftward tilt of the primitive gut tube, imparted by left-right asymmetries in the architecture of the dorsal mesentery. In silico analysis suggests that this is achieved by synergistic changes in its epithelium and mesenchyme. Within the mesenchymal compartment, cells are more densely packed on the left than on the right. In silico results indicate that this property can result from asymmetries in both extracellular matrix (ECM) and cell:cell adhesion. We find that the dorsal mesentery ECM is indeed left-right asymmetric and moreover that the adhesion molecule N-cadherin is expressed exclusively on the left side. These asymmetries are regulated by the asymmetrically expressed transcription factors Pitx2 and Isl1. Functional studies demonstrate that N-cadherin acts upstream of the changes in the ECM and is both necessary and sufficient to explain the asymmetric packing of the mesenchymal cells. 10.1073/pnas.0803578105}, author = {Kurpios, Natasza A. and Ibanes, Marta and Davis, Nicole M. and Lui, Wei and Katz, Tamar and Martin, James F. and Belmonte, Juan C. and Tabin, Clifford J. }, citeulike-article-id = {2925451}, doi = {10.1073/pnas.0803578105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {test}, month = {June}, number = {25}, pages = {8499--8506}, posted-at = {2008-06-25 19:28:24}, priority = {2}, title = {Inaugural Article: The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion}, url = {http://dx.doi.org/10.1073/pnas.0803578105}, volume = {105}, year = {2008} }

TY - JOUR ID - citeulike:2925451 L3 - citeulike-article-id:2925451 TI - Inaugural Article: The direction of gut looping is established by changes in the extracellular matrix and in cell:cell adhesion JF - Proceedings of the National Academy of Sciences VL - 105 IS - 25 SP - 8499 EP - 8506 N2 - The counterclockwise coiling of the intestines is initiated by a leftward tilt of the primitive gut tube, imparted by left-right asymmetries in the architecture of the dorsal mesentery. In silico analysis suggests that this is achieved by synergistic changes in its epithelium and mesenchyme. Within the mesenchymal compartment, cells are more densely packed on the left than on the right. In silico results indicate that this property can result from asymmetries in both extracellular matrix (ECM) and cell:cell adhesion. We find that the dorsal mesentery ECM is indeed left-right asymmetric and moreover that the adhesion molecule N-cadherin is expressed exclusively on the left side. These asymmetries are regulated by the asymmetrically expressed transcription factors Pitx2 and Isl1. Functional studies demonstrate that N-cadherin acts upstream of the changes in the ECM and is both necessary and sufficient to explain the asymmetric packing of the mesenchymal cells. 10.1073/pnas.0803578105 KW - test AU - Kurpios, Natasza AU - Ibanes, Marta AU - Davis, Nicole AU - Lui, Wei AU - Katz, Tamar AU - Martin, James AU - Belmonte, Juan AU - Tabin, Clifford PY - 2008/06/24/ UR - http://dx.doi.org/10.1073/pnas.0803578105 ER -