Alternative splicing and genome complexity.

by: D Brett, H Pospisil, J Valcárcel, J Reich, P Bork

Nat Genet, Vol. 30, No. 1. (January 2002), pp. 29-30.

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Referat

Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.

@article{citeulike:399605, abstract = {Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals.}, address = {Max Delbr\"{u}ck Center for Molecular Medicine, Robert-R\"{o}ssle Strasse 10, Berlin-Buch, 13125 Germany.}, author = {Brett, D. and Pospisil, H. and Valc\'{a}rcel, J. and Reich, J. and Bork, P. }, citeulike-article-id = {399605}, doi = {10.1038/ng803}, issn = {1061-4036}, journal = {Nat Genet}, month = {January}, number = {1}, pages = {29--30}, posted-at = {2008-06-24 18:21:52}, priority = {2}, title = {Alternative splicing and genome complexity.}, url = {http://dx.doi.org/10.1038/ng803}, volume = {30}, year = {2002} }

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TY - JOUR ID - citeulike:399605 L3 - citeulike-article-id:399605 TI - Alternative splicing and genome complexity. JF - Nat Genet VL - 30 IS - 1 SP - 29 EP - 30 AD - Max Delbrück Center for Molecular Medicine, Robert-Rössle Strasse 10, Berlin-Buch, 13125 Germany. SN - 1061-4036 N2 - Alternative splicing of mRNA allows many gene products with different functions to be produced from a single coding sequence. It has recently been proposed as a mechanism by which higher-order diversity is generated. Here we show, using large-scale expressed sequence tag (EST) analysis, that among seven different eukaryotes the amount of alternative splicing is comparable, with no large differences between humans and other animals. AU - Brett, D AU - Pospisil, H AU - Valcárcel, J AU - Reich, J AU - Bork, P PY - 2002/01// UR - http://dx.doi.org/10.1038/ng803 ER -

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