Sun, 06 Jul 2008 03:50:14 BST CiteULike: brembs' Liu http://www.citeulike.org/user/brembs/author/Liu CiteULike.org en-gb Copyright © 2004-2008 citeulike.org http://www.citeulike.org/user/brembs/article/2773606 <i>Science (8 May 2008), 1154456.</i><br /><br />We question whether homeostasis alone adequately explains microbial responses to environmental stimuli, and explore the capacity of intra-cellular networks for predictive behavior in a fashion similar to metazoan nervous systems. We show that in silico biochemical networks, evolving randomly under precisely defined complex habitats, capture the dynamical, multi-dimensional structure of diverse environments by forming internal models that allow prediction of environmental change. We provide evidence for such anticipatory behavior by revealing striking correlations of Escherichia coli transcriptional responses to temperature and oxygen perturbations--precisely mirroring the co-variation of these parameters upon transitions between the outside world and the mammalian gastrointestinal-tract. We further show that these internal correlations reflect a true associative learning paradigm, since they show rapid de-coupling upon exposure to novel environments. 10.1126/science.1154456 Anticipatory Behavior Within Microbial Genetic Networks Ilias Tagkopoulos Yir-Chung Liu Saeed Tavazoie doi:10.1126/science.1154456 Science (8 May 2008), 1154456. 2008-05-08T21:24:02-00:00 2008 Science 1154456 degeneracy http://www.citeulike.org/user/brembs/article/1095215 <i>Nature</i> An African origin for the intimate association between humans and Helicobacter pylori Bodo Linz François Balloux Yoshan Moodley Andrea Manica Hua Liu Philippe Roumagnac Daniel Falush Christiana Stamer Franck Prugnolle Schalk van der Merwe Yoshio Yamaoka David Graham Emilio Perez-Trallero Torkel Wadstrom Sebastian Suerbaum Mark Achtman doi:10.1038/nature05562 Nature 2007-02-08T19:36:11-00:00 Nature 0028-0836 Nature Publishing Group evolution h_pylori human_bacterial_symbiosis symbiosis http://www.citeulike.org/user/brembs/article/1023152 <i>Cell, Vol. 127, No. 7. (29 December 2006), pp. 1453-1467.</i><br /><br />SummaryMolecular analyses of Aplysia, a well-established model organism for cellular and systems neural science, have been seriously handicapped by a lack of adequate genomic information. By sequencing cDNA libraries from the central nervous system (CNS), we have identified over 175,000 expressed sequence tags (ESTs), of which 19,814 are unique neuronal gene products and represent 50%-70% of the total Aplysia neuronal transcriptome. We have characterized the transcriptome at three levels: (1) the central nervous system, (2) the elementary components of a simple behavior: the gill-withdrawal reflex--by analyzing sensory, motor, and serotonergic modulatory neurons, and (3) processes of individual neurons. In addition to increasing the amount of available gene sequences of Aplysia by two orders of magnitude, this collection represents the largest database available for any member of the Lophotrochozoa and therefore provides additional insights into evolutionary strategies used by this highly successful diversified lineage, one of the three proposed superclades of bilateral animals. Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry Leonid Moroz John Edwards Sathyanarayanan Puthanveettil Andrea Kohn Thomas Ha Andreas Heyland Bjarne Knudsen Anuj Sahni Fahong Yu Li Liu doi:10.1016/j.cell.2006.09.052 Cell, Vol. 127, No. 7. (29 December 2006), pp. 1453-1467. 2007-01-03T10:18:42-00:00 2006 Cell 127 7 1453 1467 aplysia classical conditioning instrumental invertebrate neurobiology neuroscience operant pavlovian